Bingcheng Wang, PhD
Case Western Reserve University
Harnessing the Intrinsic Tumor Suppressor Activities of EphA2 Kinase for Lung Cancer Therapy
Dr. Bingcheng Wang is studying the gene EphA2 which has a tumor suppressor function in normal cells. It is present in an inactivated form in some lung cancers. He seeks to restore EphA2 function by supplying missing molecules that the gene normal creates.
Preliminary results indicate that the size of lung tumors was reduced in preclinical models treated with Ephin-A1, an agent which is expected to activate EphA2. Studies are ongoing in order to determine the effect of EphA2 on K-Ras in lung cancer.