David Hayes, MD, MPH
The University of North Carolina at Chapel Hill
Molecular Subtypes of Non-Small Cell Lung Cancer
Dr. Hayes seeks to develop screening tests that will characterize each patient’s tumor based on its unique genetic profile. It will then be possible to correlate response to chemotherapy and also long term survival based on specific tumor characteristics.
Dr. Hayes identified four mRNA expression subtypes that have different survival outcomes, patient populations, and biological processes for lung squamous cell carcinoma. The subtypes (primitive, classical, secretory and basal) stratify patients for more precise prognosis and targeted research.
Dr. Hayes published the four identified subtypes of lung squamous cell carcinoma in Clinical Cancer Research. The papers associated with this grant represented strong foundational work which assisted the Principal Investigator to obtain tenure and move from an Assistant to an Associate Professorship. The research laboratory has grown from 2.2 full time employees to 6.7 full time employees. The Postdoctoral Fellow associated with this project has secured his own funding through the F32 Ruth L. Kirschstein National Research Service Award and has produced several significant papers.