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Previously Funded Research

2023 LCRF–Daiichi Sankyo–AstraZeneca Research Grant on Antibody Drug Conjugates

Carl Gay, MD, PhD

University of Texas M.D. Anderson Cancer Center

Research Project:

Pulmonary high-grade neuroendocrine carcinomas as indications for antibody-drug conjugates targeting TROP2 and HER2


Small cell lung cancer (SCLC) and large-cell neuroendocrine carcinoma (LCNEC) are similarly aggressive lung cancers with poor prognosis due, in part, to limited personalized treatment options. Preliminary data demonstrate that TROP2 and HER2 are viable targets for treatment of these malignancies if the correct patients are selected. Antibody-drug conjugates targeting TROP2 and HER2 rely upon both expression of the antibody’s target and sensitivity to the drug to which the antibody is conjugated – each of which is heterogeneous in SCLC and LCNEC. This proposal highlights a strategy to delineate the precise patient population to which to apply these agents making use of an unparalleled collection of patient samples and patient-derived models for validation.