David Reisman, MD, PhD
University of Michigan
Alteration in the SWI/SNF Chromatin Remodeling Complex in Bronchioalveolar Carcinoma
Dr. Reisman is investigating the molecular mechanisms behind bronchioalveolar carcinoma. His work is focus one two proteins, BRM and BRG1, as a part of a larger complex (SWI/SNF) that controls many cellular functions, including cell growth. To target these proteins, Dr. Reisman is investigating which components are affected in BAC using cell lines and mouse models. This research will benefit BAC patients, not only by providing a means of understanding the biology of this disease, but also by giving us important insight into possible treatments.
Dr. Reisman’s work demonstrates that BRG1 may be a valuable biomarker that can guide medical decision making regarding treatment with targeted therapies such as Tarceva or chemotherapies. Moreover, the loss of BRM appears to be a promising clinical target for therapy. Further work will flush out the utility of these genes in clinical practice.