Viji Shridhar, PhD
Mayo Clinic Cancer Center, Rochester
Functional Characterization of HSulf-1 Loss in Bronchioalveolar Carcinoma
Dr. Shridhar is investigating HSulf-1, a protein she has found commonly lost or reduced in BAC. Her studies will investigate how HSulf-1 is decreased, whether that reduction correlates to clinical outcomes, and determine whether HSulf-1 levels can be used as a predictive marker of response to treatment.
Dr. Shridhar has identified a number of candidate mutations, she is still searching for the alterations that lead to decreased HSulf-1. However, her investigation has shown a strong correlation between low HSulf-1 expression and high grade tumors. Additionally, the work has shown that HSulf-1 downregulation could be used as marker to predict increased responsiveness to targeted therapy.