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Previously Funded Research

2007 UALC

Federico Innocenti

Federico Innocenti, MD, PhD

The University of North Carolina at Chapel Hill

Research Project:

Genetics of VEGFR-2 in Bronchioalveolar Carcinoma


Dr. Innocenti is investigating differences in the genes that determine how new blood vessels are formed (angiogenesis). He will be analyzing the vascular endothelial growth factors receptor 2 (VEGFR2), to see how the activity and levels of this protein vary in different BACs, and determine if there is a genetic basis for the differences observed in patients with BAC.

More Content:

Final Report
Dr. Innocenti has found altered expression of these genes in BAC tumor samples compared to normal tissue. He has also identified a heritable gene variation that may reduce expression of VEGRF-2 in adenocarcinoma with BAC features. Further studies are warranted to expand the sample size to replicate and validate these findings.

Federico Innocenti