2007 UALC
Federico Innocenti, MD, PhD
The University of North Carolina at Chapel Hill
Research Project:
Genetics of VEGFR-2 in Bronchioalveolar Carcinoma
Summary:
Dr. Innocenti is investigating differences in the genes that determine how new blood vessels are formed (angiogenesis). He will be analyzing the vascular endothelial growth factors receptor 2 (VEGFR2), to see how the activity and levels of this protein vary in different BACs, and determine if there is a genetic basis for the differences observed in patients with BAC.
More Content:
Final Report
Dr. Innocenti has found altered expression of these genes in BAC tumor samples compared to normal tissue. He has also identified a heritable gene variation that may reduce expression of VEGRF-2 in adenocarcinoma with BAC features. Further studies are warranted to expand the sample size to replicate and validate these findings.