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Previously Funded Research

2016 Free to Breathe Metastasis Research Grant

trever bivona

Trever Bivona, MD, PhD

University of California, San Francisco

Research Project:

Discovery and Therapeutic Exploitation of a Novel Metastatic Signaling Axis in Lung Cancer

Summary:

Many changes in regulatory proteins and signaling pathways have been associated with the growth and spread of tumor cells. In some types of cancers, including lung cancer, ways to target signaling pathways have led to effective treatments. The goal of Dr. Bivona’s project is to look at new ways to disrupt signaling pathways to prevent or stop metastasis of lung cancer. Dr. Bivona’s laboratory had previously discovered that a regulatory protein known as Capicua (CIC) can help suppress metastasis. This protein has been shown to be deregulated or blocked by a signaling pathway known as the MAPK pathway. The MAPK pathway is involved in processes such as tumor cell migration, invasion and metastasis. The study will test whether drugs that block MAPK signaling can boost CIC function and, ultimately, prevent or stop metastasis. Suppressing lung cancer metastasis in a new way could improve survival of patients with lung cancer.

trever bivona