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Previously Funded Research

2023 LCRF Leading Edge Research Grant Program

Francisco Expósito, PhD

Yale University

Research Project:

Investigating novel synthetic lethal vulnerabilities in EGFR-driven lung cancer


Lung cancers driven by mutations in EGFR represent between 15-60% of lung adenocarcinomas. The presence of EGFR mutations predicts the response to specific therapies referred to as tyrosine kinase inhibitors (TKIs). Although these inhibitors have revolutionized the way we treat this type of cancer, patients have varied responses and eventually, all tumors will become resistant and stop responding, highlighting the need for alternative treatment options.

In this project, we aim to understand how the loss of SETD2 hinders EGFR-driven tumor growth to leverage these findings to create new precision treatments for the treatment of patients with EGFR-mutant tumors.

This project was awarded the LCRF William C. Rippe Award for Distinguished Research in Lung Cancer, acknowledging the investigator whose proposal not only demonstrated exceptional scientific merit but also exemplified an enduring commitment to making an impact in the field of lung cancer research.

I am really honored to receive the William C. Rippe Award for Distinguished Research in Lung Cancer from the Lung Cancer Research Foundation. Thanks to the support from LCRF we hope to uncover novel genetic vulnerabilities of EGFR-driven lung tumors and leverage these findings to implement and inform new precision-based treatments for this type of tumors in the future.