Investigators from China and Spain have recently published an article describing a new technology integrating ultrasensitive Pt@InNiOX nanoflakes into a portable electronic device. This device may be used to diagnose lung cancer by breath analysis. (Cheng Y et al, American Chemical Society Sensors, Nov. 6, 2024)
Why it’s important
Gas sensors have been used in a variety of fields including healthcare. The makeup of human breath is very complicated because it contains many different compounds. Isoprene is one of these compounds that has the potential for detecting lung cancer. The idea of analyzing breath to diagnose lung cancer is not new and has not been successful. Many challenges are involved in breath analysis, including the ability to selectively detect isoprene at very low levels. Additional problems include the breath’s natural humidity and the difficulty in analyzing breath in real time so that it is a practical tool. The researchers have developed an indium (III) oxide (In2O3)-based nanoflake sensor (Pt@InNiOX) that detects isoprene at very low levels (2 parts per billion, ppb), is more selective for isoprene, has a consistent performance, and is able to be incorporated into a portable device.
What it means for patients
The researchers tested the device in 13 patients, 5 of whom had lung cancer. According to the results, exhaled isoprene concentrations in lung cancer patients consistently fell below 40 ppb, in contrast to levels exceeding 60 ppb in healthy individuals. This portable sensor has the potential to be a cost-effective way of diagnosing lung cancer. If further research is successful, this technology could be used as a screening tool in conjunction with standard screening involving low dose computerized tomography (LDCT). Since there is a significant incidence of lung cancer in never smokers who do not meet screening criteria, it could also be important in detecting lung cancer in these individuals. The device is not ready for “prime time.” Rigorous clinical trials will need to be done to assess the relationship between isoprene detection and the diagnosis of lung cancer.
What to look for
Expect to see clinical trials employing this device as an adjunct to cancer diagnosis and screening. These studies will be used to refine the technology and determine the best way to employ this tool in the detection and management of lung cancer. The sensing device could provide a breakthrough in noninvasive lung cancer screening and has the potential to improve healthcare and even save lives.
Groups award $2.5 million, four-year research grant to team led by Dr. David Barbie of Dana-Farber Cancer Institute
NEW YORK, NY (November 19, 2024) – The Lung Cancer Research Foundation (LCRF) and the International Association for the Study of Lung Cancer (IASLC) today announced their first IASLC – LCRF Team Science Research Grant on the Next Step in the Cure of Oncogene-Driven Lung Cancers. David A. Barbie, MD, Director of the Lowe Center for Thoracic Oncology at Dana-Farber Cancer Insititute, and principal investigator of the Barbie Lab, will be leading the winning project, “Immune elimination of drug tolerant persister cells in oncogene-driven lung cancer.” The research team is comprised of Dr. Barbie as principal investigator; Aaron Hata, MD, PhD of Massachusetts General Hospital; Eric Smith, MD, PhD of Dana-Farber Cancer Institute; Pasi Jänne, MD, PhD of Dana-Farber Cancer Institute; and Shunsuke Kitajima, PhD representing the Japanese Foundation for Cancer Research.
Lung cancer is responsible for more deaths worldwide than any other cancer, accounting for an estimated 130,180 deaths annually in the United States alone. In the last 10 to 15 years, accelerated clinical trials and FDA approvals of targeted therapies for non-small cell lung carcinoma have been possible in part due to advances in molecular profiling of tumors. Many of these targeted therapies are directed against oncogenic drivers, with EGFR as one of the first oncogenic drivers that was successfully targeted with the use of tyrosine kinase inhibitors (TKIs.)
Tyrosine kinase inhibitors are effective at controlling the disease but eventually the lung cancer cells develop resistance to treatment and patients are not cured. The goal of this Team Science Award is to investigate strategies that will lead to a cure for oncogene-driven lung cancer. It is thought that some lung cancer cells persist after treatment. These drug tolerant persister (DTP) cells eventually result in progressive cancer. There has been a lot of interest in studying DTP cells to see if vulnerabilities can be identified that can be targeted earlier to destroy these cells before disease progression results. Most oncogene-driven lung cancers are “cold” tumors and do not respond to immunotherapy, though these DTP cells may have vulnerabilities in their immune makeup that renders them susceptible to immunotherapy.
Dr. Barbie and his research team have identified a negative regulator of an immune pathway in DTP cells. By inhibiting this negative regulator, they plan to unleash an immune attack on the DTP cells. The hope is that these studies may define a new therapeutic approach that could make the DTPs more sensitive to being killed by immunotherapy. There are a number of agents being developed that could be useful in inhibiting the negative immune regulator thus making this concept feasible for transitioning to a clinical trial for patients. In addition, there are proteins in malignant DTP cells that make them ideal targets for treatment. Once the presence of those proteins is confirmed, and CAR-T cells generated, the team will test the negative immune regulator in combination with the CAR-T cells to treat the oncogenic-driven lung cancer.
“It is a very exciting time for lung cancer research, and we are confident that our team will uncover approaches that will make a difference for patients living with oncogenic-driven lung cancer,” says Dr. David Barbie. “This award will allow us to make significant impact that will hopefully result in a clinical trial.”
“Being able to stop resistance before it begins would be practice-changing for oncologists and life-saving for patients,” says Dr. Antoinette Wozniak, Chief Scientific Officer for LCRF. “Working together – funders, patients and research teams – we can help move science forward, faster. LCRF is thrilled to be partnering with IASLC to fund this project and this team of researchers.”
“We believe that multidisciplinary, international partnerships will accelerate the pace of research, and we are excited to support impactful collaborative science,” says Dr. Jennifer C. King, Chief Science Officer, IASLC. “We’re pleased to join forces with LCRF on this first Team Science award, and hope Dr. Barbie and team’s innovative research program is an important step toward the goal of curing oncogenic-driven lung cancer.”
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About the Lung Cancer Research Foundation (LCRF) The Lung Cancer Research Foundation® (LCRF) is the leading nonprofit organization focused on funding innovative, high-reward research with the potential to extend survival and improve quality of life for people with lung cancer. LCRF’s mission is to improve lung cancer outcomes by funding research for the prevention, diagnosis, treatment, and cure of lung cancer. To date, LCRF has funded 420 research grants, totaling nearly $45 million, the highest amount provided by a nonprofit organization dedicated to funding lung cancer research. For more information about the LCRF grant program and funding opportunities, visit lcrf.org/research.
About IASLC The International Association for the Study of Lung Cancer (IASLC) is the only global organization dedicated solely to the study of lung cancer and other thoracic malignancies. Founded in 1974, the association’s membership includes more than 10,000 lung cancer specialists across all disciplines in over 100 countries, forming a global network working together to conquer lung and thoracic cancers worldwide. The association also publishes the Journal of Thoracic Oncology, the primary educational and informational publication for topics relevant to the prevention, detection, diagnosis and treatment of all thoracic malignancies. Visit www.iaslc.org for more information.
Contact:
LUNG CANCER RESEARCH FOUNDATION (LCRF) Sheila Sullivan Sr. Director, Marketing & Communications ssullivan@lcrf.org
INTERNATIONAL ASSOCIATION FOR THE STUDY OF LUNG CANCER (IASLC) Chris Martin IASLC Media Relations cmartin@davidjamesgroup.com
Ivan Auyeung decided to raise funds for lung cancer research after his father passed away earlier this year. When his family learned his diagnosis, they were told he had only 5 years left to live – yet that was cut down to an even shorter 9 months.
“My goal was to help a small part of a much bigger problem in our world and hope that this can be used to help patients and their families who are currently undergoing the same struggle my father and my family did less than a year ago.”
Ivan engaged the volleyball community by selling custom board shorts (named “IE Reverse Blossom”). He worked with Slunks, a company that sells board/volleyball shorts that are a big niche in the men’s volleyball community. With his platform on Instagram, @slunks.IE, as well as at his volleyball club, Houston Volleyball Academy, he was able to not only raise awareness but sell 194 pairs of shorts to raise $7,800!
Special thanks to Ivan, his family, his designer, @southshorecreatives on Instagram, and the administrators at the Houston Volleyball Academy!
The design was promoted on InstagramShipping dayModeling the finished shorts
Coral Olazagasti , MD, and Estelamari Rodríguez, MD, MPH, led a Lung Cancer Community Talk in Spanish on November 7. With moderator Ana Velázquez Mañana, MD, MSc, they provided an overview of lung cancer, with a discussion about lung cancer diagnosis and treatment, biomarker testing, clinical trials, and more.
Dr. Olazagasti is a head & neck and thoracic oncologist for Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine. Dr. Rodriguez is Co-Lead, Thoracic Site Disease Group for the institution. Dr. Velázquez Mañana is a thoracic oncologist and an Assistant Professor of Medicine at the University of California, San Francisco.
Watch the recording below.
La Dra. Coral Olazagasti y la Dra. Estelamari Rodríguez nos acompañaron a una discusión comunitaria sobre el cáncer de pulmón el jueves 7 de noviembre. Moderado por la Dra. Ana Velázquez Mañana, brindaron una descripción general del cáncer de pulmón y discutieron el diagnóstico y el tratamiento del cáncer de pulmón, las pruebas de biomarcadores y los ensayos clínicos, entre otros temas.
La Dra. Olazagasti es oncóloga de cabeza y cuello y oncóloga torácica en el Sylvester Comprehensive Cancer Center de la Escuela Miller de Medicina de la Universidad de Miami. La Dra. Rodríguez es codirectora del Grupo de Tumores Torácicos de la institución. La Dra. Velázquez Mañana es oncóloga torácica y catedrática adjunta de Medicina en la Universidad de California, San Francisco.
LCRF’s 2024 Scientific Symposium was held November 4 as part of our Lung Cancer Awareness Month activities. Joining the record-breaking group online were event lead and moderator, Kathryn O’Donnell, PhD; our chat moderator, Isabel Preeshagul, DO, MBS; and speakers Brendon M. Stiles, MD; Colleen Conner Ziegler; Mark Awad, MD, PhD; Hossein Borghaei, DO, MS; Lauren Averett Byers, MD; Joseph A. Greer, PhD; and Don Nguyen, PhD, BSc.
Introducing our 2024 Team LCRF runners who will be doing the TCS New York City Marathon on November 3! Read more below about this year’s amazing group of marathoners who are raising awareness and fundraising for lung cancer research.
“The Lung Cancer Research Foundation holds a special place due to the emotional impact of losing my mother in July 2022. Supporting this foundation becomes a meaningful way to channel grief into a positive force, contributing to vital research that may prevent others from enduring similar losses. It transforms personal pain into a collective effort for a cause that holds deep personal significance.”
“I am so happy to be a part of Team LCRF so that I can fundraise and run in honor of my dad, who I lost to small cell lung cancer in 2017. I truly believe in the power of science and research that can make a difference for others moving forward.”
Proudest running accomplishment: “Running a ‘redemption’ half where I was able to finish faster and stronger than my first try!”
Best training partners: “I’m lucky to have two of my best friends as training partners. We are each other’s biggest cheerleaders and help to hold each other accountable when it gets hard! I could never train or finish any race without them.”
“I’m running in honor of my grandfather, who was diagnosed with lung cancer in 2022. He is and always has been my biggest supporter, although he still doesn’t quite understand why I enjoy running so much. LCRF does critical work in support of all those affected by lung cancer, and I’m thrilled to be a part of the Team and run for a cause personal to me and my family.”
Proudest running accomplishment: “Finishing the 2023 Marine Corps Marathon, my first.”
Favorite food while training: “Pizza and ice cold Diet Coke”
“I lost my mother in January to lung cancer so I am running in her memory. Between the personal link with family and what I see in my patients daily, I know the importance of research into more accessible treatments and hopefully a cure.”
“Lung cancer has had a direct impact on my family having lost my father, my father-in-law, my uncle and an aunt-in-law and uncle-in-law. I have experienced this disease as a caregiver and as someone who has lost many loved ones. I first started running in support of my father as he battled this disease in my first Free to Breathe walk over 9 years ago. I now run in memory of him and in support of this disease that I truly believe with this type of support can one day have a cure.”
Proudest running accomplishment: “My very first 5k over the Brooklyn Bridge with Free to Run Brooklyn in 2015 with my Dad cheering me on as he was mid treatment. And finishing my first half marathon 2024!”
On my playlist: “Whitney Houston’s greatest hits are always part of my running playlists!”
“NYC is Marathon #5 for me, and being a part of team LCRF is special for me as I raised money in honor of a close friend whose life was cut short by lung cancer, Kelley (Kuntz) MacDonald. I’m proud to represent such a great organization and do it while getting the opportunity to run, something Kelley and I both loved.”
Proudest running accomplishment: “Running my first sub-4 marathon at the 2023 Chicago marathon”
On my playlist: “I either run to EDM mash-ups, true-crime podcasts, or Ed Sheeran :)”
“In running this marathon, I am hoping to do more than honor the memory and strength of the loved ones I’ve lost to lung cancer. I want to raise funds to support the vital research efforts of the Lung Cancer Research Foundation. With every stride and drop of sweat, I aim to contribute towards a future where no one loses a family member or a friend to lung cancer. “
Proudest running accomplishment: “In high school I ran a 4:34 mile!”
On my playlist: “I listen to live shows from EDM artist Fisher.”
“I’m joining Team LCRF for the 2024 NYC Marathon in honor of my grandmother, who battled lung cancer throughout my childhood.”
Proudest running accomplishment: “Running the NYRR Fred Lebow Half-Marathon with my sister, Julia.”
Rest day routine: “On my rest day, I like to relax by cooking and watching TV shows.”
“I am running in honor of my mother Elaine, whose life was cut (way too) short at 47 by lung cancer, and to make my wife (Hayley) and kids (Emma and Alex) proud. While my family never had the opportunity to meet my mother, the older I get, the more I realize how similar I am to her. She was an avid runner and would be so proud of my accomplishments.
Training for a marathon while holding down a full time job and parenting two young kids is no easy feat; however, it pales in comparison to battling lung cancer. I am pushing my lungs to the max for those who can’t and with hope that in time, we will have a cure.”
Proudest running accomplishment: “Crossing the finish line at the 2023 New York City Marathon! Now it’s time to take everything I have learned and apply it for round two.”
Favorite food while training: Lots of pizza the night before a race!
“I have lost two amazing people to lung cancer who lived active and healthy lives. My father passed away in 2002 and was my lifelong ski buddy! Isabella De La Houssaye was a friend that showed how to live an active life. I am running for them!”
Proudest running accomplishment: “Just finished a ten mile race in 6:50 splits.”
Favorite food while training: “Homemade Bolognese”
“Running with Team LCRF is a great honor. My grandma, Margaret Ward, battled lung cancer for many years and I am honored to be able to run in memory of her. My fond memories of her wit and laughter will be a huge boost for me on the course.”
Proudest running accomplishment: “Running the Brooklyn Half in 1hr 36min!”
Favorite food while training: “Favorite food while training has got to be al pastor tacos.”
“Being a part of Team LCRF is so important to me because my mom was unexpectedly diagnosed with lung cancer in April of 2023. As a non-smoker, this diagnosis came as a total shock to our family and we searched for answers. My mom has continued to fight over the last year, so the least I can do is run 26.2 miles to help end lung cancer!”
Proudest running accomplishment: “Running the Boston Marathon three times!”
On my playlist: “My running playlist consists of Taylor Swift, Dua Lipa, and Noah Kahan.”
“I usually run in trail ultra events but thought if I am going run a big city marathon I would want to take the opportunity to raise some money that can make a real difference to people’s lives.”
Proudest running accomplishment: “My longest run to date: The West Highland Way in Scotland. 96 miles from Glasgow to Fort William.”
Favorite food while training: “Salt and vinegar crisps (chips) and bananas on long training runs.”
“I have been an oncology hematology nurse for 9 years and have worked closely with many patients who are battling lung cancer. I am running for my patients!!”
Proudest running accomplishment: “Surfer Santa 5k, where I placed 1st”
Best training partner: “Chelsea has been my training partner, motivating each other on long runs.”
On my playlist: “Creed, Nickelback, and of course Biggie.”
“I’m running to support the research surrounding Lung Cancer in honor of Reina Honts. I’m a squash coach for Reina’s daughter and have formed a strong connection with the Honts family and their story. I admire Reina for what she has overcome and I would like to do my part in helping support LCRF. Thank you for the opportunity!”
Proudest running accomplishment: “Completing the LA Marathon 2023”
“I am running in honor of my grandfather who I lost to lung cancer many years ago. Although I was young, I remember how much he and his loved ones suffered. By fundraising for Team LCRF, I hope to help improve lung cancer patients’ chances of survival and quality of life.”
Proudest running accomplishment: “Ran a 15K Tough Mudder on Stratton Mountain!”
“Being a part of Team LCRF is important to me because I’ve seen the effect of lung cancer first hand. I want to put an end to it. The incredible stories of how the LCRF has impacted individuals lives throughout their cancer journey has inspired me to run and help them in their fight.”
Proudest running accomplishment: “Running the Dopey 4-Day Challenge. It was a back-to-back running race that started with a 5km run Thursday, 10km run Friday, 1/2 marathon Saturday and finished with a Full Marathon on Sunday!”
Favorite food while training: “Favorite food while training has been the Honey Stinger fruit smoothie gels! They’re actually tasty and go down super smooth.”
“We are inspired by our generous, kind, forever supportive father, who is currently kicking lung cancer’s ass. As anyone lucky enough to know him can attest, his tremendous joy for life is infectious. LCRF has been instrumental in developing targeted therapy treatments that can be a game changer for families like ours. Your support means the world to us!”
“I want to raise as much money as possible to help the affected and their loved ones. LCRF is an organization near and dear to my family’s heart and I am honored to have the opportunity to run for them.”
This year’s Pittsburgh Chinese Golf Association (PCGA) Annual Tournament was dedicated to PCGA’s founder and president, Dr. Baocheng Zhang, who passed away in May from lung cancer. The event was held October 13 at Quicksilver Golf Club in Midway, PA, and raised $10,650 for lung cancer research.
After golf, the 44 participants gathered for an awards ceremony which included a special dedication to Dr. Zhang. Special thanks to Eddie Zhang, Dr. Baocheng Zhang’s son, for planning this event in memory of his father.
Business sponsors included: Westinghouse Electric Company, Shanghai Tokyo / Zen Restaurant and Sushi Bar (Joe Zhou), Beyond Education International (Mike Lin), Pho Van Pittsburgh (Steve Weng), Smart Financial Group (DJ Ng), General Mortgage Capital Corporation (Amanda Liu). Generous personal donations came from Eddie Zhang, Ben Zhao, Adam Yuan, Yun Long, Ziqing Zhang, Yimin Lu, and Eugene Zhang.
Free to Breathe Walk weekend gave survivors, caregivers, friends, family, medical staff, and other supporters an opportunity to join forces to fund lung cancer research.
Walk events took place in Chicago and Kansas City, and others were invited to join the Free to Breathe Anywhere Walk in their own neighborhoods. Walkers and their teams will continue to fundraise through the end of the year.
In Kansas City, 120 participants raised $20,000 and enjoyed an uplifting day of community which included a 3-mile walk route. Special thanks to committee members Stephanie Brunkhorst, Steve Shelton, and Shana Abdullah for their efforts to bring the event to life. Steve shared his own lung cancer story during the opening ceremony.
Chicago‘s walk brought 550 participants together who raised over $140,000 for research. The morning featured family friendly activities such as face painting and tae kwon do, as well as a 2-mile walk route. LCRF board member Tejal Patel was the emcee for the opening ceremony, and Michelle Cihla shared her story as a survivor.
Learn more about the Free to Breathe program at LCRF.org/walk.
Anywhere Walk teams participated from places as varied as California, Colorado, New Hampshire, and Washington, DC – with more walking in the coming weeks. Watch the Free to Breathe Anywhere Walk opening ceremony here:
The Food and Drug Administration (FDA) has approved amivantamab-vmjw for two new indications for the treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC) with common epidermal growth factor receptor (EGFR) exon 19 deletions and exon 21 L858R substitution mutations.
Why it’s important
Amivantamab is a bispecific antibody which means that it has two different targets, EGFR and MET. It has already been approved in the treatment of NSCLC with EGFR exon 20 insertion mutations
The first new approval is for the initial treatment of advanced NSCLC with common EGFR mutations. This was based on the results of the MARIPOSA trial. In this study, over 1,000 patients were treated with lazertinib with or without amivantamab or osimertinib. The outcome of the trial indicated that the length of time the cancer was controlled [progression-free survival (PFS)] was 23.7 months for the lazertinib and amivantamab group and 16.6 months for patients treated with osimertinib alone. It was too early to determine whether the patients who received lazertinib and amivantamab lived longer.
The second approval came from the MARIPOSA-2 study. Patients with advanced NSCLC with common EGFR mutations whose disease progressed after osimertinib received chemotherapy with or without amivantamab or amivantamab alone. The PFS was 6.3 months for patients who received the chemotherapy plus amivantamab compared to 4.2 months for the patients who received chemotherapy alone. There was no significant improvement in the survival of the patients who received both drugs, but the results are still early, and an additional analysis will be needed.
What it means for patients
Many advances have been made with the treatment of patients with EGFR mutant NSCLC. The fact that amivantamab has been FDA approved for initial treatment and after disease progression is a clear indication that progress is being made. This is very important because patients with advanced disease are usually not cured with current therapy. The use of amivantamab represents another available treatment option. It should be noted that using two treatments instead of one does come with more side effects, but these were managed on both MARIPOSA trials. It is important to discuss these new treatments along with their benefits and side effects with your oncologist.
What to look for
There are trials that are trying to minimize the side effects of amivantamab to make treatment easier. For instance, work is being done to allow the drug to be given via a needle under the skin rather than through the vein. This reduces the infusion reactions and lessens the time needed to deliver the drug. Even more important research is continuing in this field with the development of new agents, and efforts are underway to understand the reasons these cancers become resistant to treatment. The ultimate intention of these efforts is to find a cure for patients with NSCLC and EGFR mutations.
The Lung Cancer Research Foundation’s annual Evening of Innovation gala celebrated scientific discovery and the remarkable people who have contributed to the progress being made in the lung cancer space. The event raised more than $650,000 for lung cancer research that will continue lifesaving breakthroughs in diagnosis and treatment.
This year’s gala, held at The Metropolitan Club in Manhattan on Sept. 24, honored Mark G. Kris, MD, thoracic oncologist and the William and Joy Ruane Chair in Thoracic Oncology at Memorial Sloan Kettering Cancer Center. Dr. Kris was a vital member of LCRF’s Scientific Advisory Board for over 10 years and played an essential role in building its research program. His guidance to the founding members of LCRF shaped its strategic trajectory, and his leadership and direction empower LCRF to fund the brightest minds and make the biggest impact for patients.
Dr. Kris with Mary Ann Tighe & Dr. David HidalgoDr. Kris accepts his award
From the speech given by Dr. David Hidalgo outlining the highlights of Dr. Kris’s extraordinary career; to the testimonials given by patient Tejal Patel and others whose lives he touched; to the special guest appearance of Debby Boone; to the applause of the room; and the sheer number of family, friends, colleagues, mentors and mentees in attendance; it was a truly meaningful evening.
Dr. Kris, in his acceptance speech, acknowledged everyone that helped shape his career as a clinician and a scientist, and shared his vision of the future of lung cancer research. He began and ended by encouraging everyone in the room to work toward a cure for lung cancer. “When you lay your head down on the pillow tonight, dream about a cure. Because if you can dream of it, a cure can happen.”
“Life can turn on a dime.” It’s a phrase we all know. Yet at age 62, I never thought that saying would apply to me.
But it did. My life was forever changed on a cold morning in January 2017 at my first appointment with Dr. Mark Kris.
Dr. Kris told me I had Stage Four lung cancer and that I was a very sick woman. He urged me to get my financial affairs in order and that I qualified as “disabled” in medical parlance.
My focus instantly shifted to receiving the best medical care possible to extend my life. And thus began my continuing journey with Dr Kris, one that has had its ups and downs, but that makes me hopeful it will last many more years.
Early on, Dr. Kris recommended I participate in a drug trial protocol that combined Avastin and Tagrrisso, two different cancer drugs. Today, I remain on Tagrisso.
Because the tumors had shrunk substantially I was then able to have surgeries at the one-year and 4-1/2-year marks to remove cancerous tissue from my right lung. But today, I am “no evidence of disease,” I feel great, and I walk more than five miles daily.
I attended my son’s wedding in 2022, I continue to work, and I enjoy a full and rich life. For all of this, I have Dr. Kris to thank.
For the last seven years, I have depended on his medical prowess, as well as his empathy and attention. I think of him as my savior and real-life guardian angel.
Dr. Kris saved my life, against all odds. I remain on his prescribed therapy regimen, and he continues to oversee the treatment of my disease. I give thanks to Dr. Kris with every breath I take.
I am so grateful to you, Dr. Kris. A heartfelt thanks to you for saving my life and those of so many others. Your extraordinary reputation is widespread.
When others ask me who my physician is and I tell them it’s Dr. Kris, the responses are unanimous. “He’s the best,” they tell me. And that is absolutely true.
